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For inhalation exposure, both the lungs and kidneys are target organs for cadmium-induced toxicity (ATSDR, 1989; Goyer, 1991). There is limited evidence from epidemiologic studies for cadmium-related respiratory tract cancer (ATSDR, 1989). Toxicological profile for cadmium. (1) Agency for Toxic Substances and Disease Registry (ATSDR) Cadmium that enters the body tends to accumulate in the kidney and liver. Agency for Toxic Substances and Disease Registry (ATSDR). Each profile will be revised and republished as necessary. Toxicological Profile for Lead. The Agency for Toxic Substances & Disease Registry (ATSDR) offers a self-instructional module on “Taking an Exposure History” which provides an exposure history form in Appendix 1. Each profile will be revised and republished as necessary. Cadmium toxicity occurs when a person breathes in high levels of cadmium from the air, or eats food or drinks water containing high levels of cadmium. 1993. The reasons it is higher are: 1) use of more recent toxicity information; and 2) rouding to one n significant digit. Cadmium is a naturally occurring metal. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Services. Agency for Toxic Substances and Disease Registry (ATSDR). 1993. The original guidelines were published in the Federal Register on April 17, 1987. Therefore, toxicity of cadmium generally results from chronic exposure. The 2015 acute health Risk Limit (HRL) for cadmium (5 µg/L) is slightly higher than the 1993 HRL of 4 µg/L. Agency for Toxic Substances and Disease Registry Division of Toxicology and Environmental Medicine ToxFAQs TM September 2008 This fact sheet answers the most frequently asked health questions (FAQs) about cadmium. It is usually present in the environment as a mineral combined with other elements like oxygen, chlorine, or sulfur. Both the liver and kidneys store cadmium as a metallothionein complex, which serves not only to transport cadmium but also acts as a defense mechanism against the toxicity of the unbound cadmium ion. Cadmium in the kidneys can have a half-life of several decades. Cadmium is an accumulative toxicant with a long biological half‐life that has been estimated to be 10 to 33 years in humans, which results in increased body burden over time (Clemens et al., 2013; EFSA, 2009). 2012. This toxicological profile is prepared in accordance with guidelines * developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). Tweet this: “ATSDR’s Toxic Substances Portal is an easy reference for researchers & individuals to find information about toxic chemicals, understand how they can affect health, and learn how to prevent exposure.Visit https://bit.ly/2JOOIif #CDCEHblog via @CDCEnvironment” Atlanta: U.S. Department of Health and Human Services, Public Health Service. Cadmium in the blood indicates recent exposures, while cadmium in the urine is related to the concentration of cadmium in the kidneys (ATSDR, 2008). The kidney is the critical target and shows the earliest sign of cadmium toxicity. Absorbed cadmium accumulates mainly in the kidney and liver, with an estimated half-life of 6–38 years, and 4–19 years, respectively, and no direct metabolism is known (ATSDR, 2012). Toxicological Profile for Cadmium. 5.Agency for Toxic Substances and Disease Registry (ATSDR). 6.Agency for Toxic Substances and Disease Registry (ATSDR). Case studies in environmental medicine: Cadmium toxicity. 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